C（3〜6か月） 繁殖効率：A ホモにて継代 phage P1 loxP site, mouse Neurochondrin genomic DNA C (3-6 months) Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="http://akif2.tara.tsukuba.ac.jp/Top_iweb/Welcome_en.html" target="_blank">Lab HP (Japanese)</A> 国立大学法人筑波大学 Neurochondrin conditional knock-out mice. The neural tissue-specific neurochondrin is disrupted by Cre-loxP system. Neurochondorin is a cytoplasmic protein involve in neurite outgrowth, chondrocyte differentiation, and bone metabolizm. The nervous system specific deficient mice show that the Ncdh gene is a negative regulator to CaMKII (Ca/calmodulin-dependent protein kinase II) and essential for the spatial learning prosess. 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Biol. Chem., 21, 20503-20508 (2005). TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] マウス・ニューロコンドリン遺伝子のプロモータを含む exon1 領域を欠損している。 NC<-/-> NC<-/-> 繁殖効率：Aホモにて継代 NC-/- NC-/- true Univ. Tsukuba B6.Cg-Ncdn<tm2.1Afu>/AfuRbrc B6.Cg-Ncdn<tm2.1Afu>/AfuRbrc Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 2004. 開発年：2004 年 開発者：深水昭吉先生 機関名：筑波大学 開発年：2004 年開発者：深水昭吉先生機関名：筑波大学 RBRC01497 In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 21, 20503-20508 (2005). Akiyoshi FUKAMIZU 深水　昭吉 Cre/loxP system